COVID-19 tagged posts

COVID-19 virus uses Heparan Sulfate to get inside cells

SARS-CoV-2’s spike protein must bind both the ACE2 receptor and heparan sulfate to gain entry into human cells

Discovery opens new possibilities for treating COVID-19 by disrupting virus’ ability to bind the carbohydrate, potentially by using a repurposed drug. Researchers discovered that the SARS-CoV-2 virus can’t grab hold of cell receptor ACE2 without a carbohydrate called heparan sulfate, which is also found on lung cell surfaces – disrupting that interaction with a repurposed drug may help treat COVID-19.

A molecule known as ACE2 sits like a doorknob on the outer surfaces of the cells that line the lungs...

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Elderly People protected against Respiratory Infections by BCG Vaccine

ACTIVATE: Randomized Clinical Trial of BCG Vaccination Against Infection in the ElderlyCell, Aug. 31, 2020; DOI: 10.1016/j.cell.2020.08.051

However, the effect of the vaccine specifically against COVID-19 has not been demonstrated. The BCG vaccine, an old treatment originally developed for tuberculosis, has a broad, stimulating effect on the immune system. This gives it an effective preventive action against various infections — possibly also against COVID-19. It is frequently given to children, but in this double-blind randomized clinical study, a collaboration between Radboud University Medical Center and the National and Kapodistrian University of Athens it was shown that elderly people also benefit from it. The results of the study are in Cell.

At Radboudumc, Professor of Expe...

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New Insights into Lung Tissue in COVID-19 disease

Sections through the three-dimensional reconstruction volume (upper left, grey) around a pulmonary alveolus with hyaline membrane (lower left, yellow). On the right, the images are superimposed. In the centre is the air bubble (alveolus). The electron density is represented by different shades of grey. On the inside of the air bubble is a layer of proteins and dead cell residues, the “hyaline membrane”. This deposit, which can be represented in its three-dimensional structure for the first time by the new method, reduces the gas exchange and leads to respiratory distress.

Photo: Tim Salditt, Marina Eckerman

Physicists at the University of Göttingen, together with pathologists and lung specialists at the Medical University of Hannover, have developed a 3D imaging technique that enables h...

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AeroNabs promise Powerful, Inhalable Protection against COVID-19

AeroNabs spray in an aerosol
Due to the inherent stability of nanobodies, there was no loss of antiviral potency in the aerosolized form, suggesting that AeroNabs are a potent SARS-CoV-2 antiviral that could be practical to administer via a shelf-stable inhaler or nasal spray. Photo by Noah Berger

As the world awaits vaccines to bring the COVID-19 pandemic under control, UC San Francisco scientists have devised a novel approach to halting the spread of SARS-CoV-2, the virus that causes the disease.

Led by UCSF graduate student Michael Schoof, a team of researchers engineered a completely synthetic, production-ready molecule that straitjackets the crucial SARS-CoV-2 machinery that allows the virus to infect our cells...

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