COVID-19 tagged posts

New Insights into Lung Tissue in COVID-19 disease

Sections through the three-dimensional reconstruction volume (upper left, grey) around a pulmonary alveolus with hyaline membrane (lower left, yellow). On the right, the images are superimposed. In the centre is the air bubble (alveolus). The electron density is represented by different shades of grey. On the inside of the air bubble is a layer of proteins and dead cell residues, the “hyaline membrane”. This deposit, which can be represented in its three-dimensional structure for the first time by the new method, reduces the gas exchange and leads to respiratory distress.

Photo: Tim Salditt, Marina Eckerman

Physicists at the University of Göttingen, together with pathologists and lung specialists at the Medical University of Hannover, have developed a 3D imaging technique that enables h...

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AeroNabs promise Powerful, Inhalable Protection against COVID-19

AeroNabs spray in an aerosol
Due to the inherent stability of nanobodies, there was no loss of antiviral potency in the aerosolized form, suggesting that AeroNabs are a potent SARS-CoV-2 antiviral that could be practical to administer via a shelf-stable inhaler or nasal spray. Photo by Noah Berger

As the world awaits vaccines to bring the COVID-19 pandemic under control, UC San Francisco scientists have devised a novel approach to halting the spread of SARS-CoV-2, the virus that causes the disease.

Led by UCSF graduate student Michael Schoof, a team of researchers engineered a completely synthetic, production-ready molecule that straitjackets the crucial SARS-CoV-2 machinery that allows the virus to infect our cells...

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Electric Cooker an easy, efficient way to Sanitize N95 Masks, study finds

One 50-minute, 212 F cooking cycle in a dry electric multicooker decontaminates an N95 respirator without chemicals and without compromising the filtration or fit.
Photo by Chamteut Oh

Owners of electric multicookers may be able to add another use to its list of functions, a new study suggests: sanitization of N95 respirator masks.

The University of Illinois, Urbana-Champaign study found that 50 minutes of dry heat in an electric cooker, such as a rice cooker or Instant Pot, decontaminated N95 respirators inside and out while maintaining their filtration and fit. This could enable wearers to safely reuse limited supplies of the respirators, originally intended to be one-time-use items.

Led by civil and environmental engineering professors Thanh “Helen” Nguyen and Vishal Verma, the...

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Transferrin identified as Potential Contributor to COVID-19 Severity

Could transferrin be a potential biomarker for COVID-19 severity?

The University of Kent’s School of Biosciences and the Institute of Medical Virology at Goethe-University, Frankfurt am Main, have identified that a glycoprotein known as transferrin may critically contribute to severe forms of COVID-19.

SARS-CoV-2 is the coronavirus that causes COVID-19. It is currently not known why some individuals develop only mild or no symptoms when infected, whilst others experience severe, life-threatening forms of the disease. However, it is known that the risk of COVID-19 becoming severe increases with age and is higher in males than in females. Many severe COVID-19 cases are characterised by increased blood clotting and thrombosis formation.

The team combined existing data on gene expres...

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