Crohn’s disease tagged posts

A new software tool allows scientists to link different human diseases and traits through the genetic variations they share. Credit: Liuyang Wang, Dennis Ko lab

A new study hints we should be paying attention to omega-6, omega-7 for improving/ worsening Crohn’s. Some research has suggested that omega-3 fatty acids can relieve inflammation. Research has suggested high-fat diets may be linked with Crohn’s disease, but never have the 2 been joined through shared genetics. Certain subtle genetic variations — as small as a single-letter change in the DNA — seem to occur more often in people with Crohn’s disease. Separate lines of work show that specific genetic variations are linked to higher levels of some fatty acids (molecular building blocks of fat) in the bloodstream.

In the new study, res...

Scientists who analyzed the genes involved in 10 autoimmune diseases that begin in childhood have discovered 22 genome-wide signals shared by 2 or more diseases. These shared gene sites may reveal potential new targets for treating many of these diseases, in some cases with existing drugs already available for non-autoimmune disorders. Autoimmune diseases, eg Type 1 diabetes, Crohn’s disease, and juvenile idiopathic arthritis, collectively affect 7 to 10% of the Western Hemisphere.

Meta-analysis was performed, incl a case-control study of 6,035 subjects with automimmune disease and 10,700 controls, all of European ancestry. Yun (Rose) Li, M.D./Ph.D...