This is a 3-D fluorescence microscopy image of a cell guidance receptor’s (EphA2) signaling activity in a cryo-arrested cell. This receptor is overexpressed in melanomas and affects metastasis. From this image taken at subzero temperatures, one can see that it is transmitting its signals from small vesicles in the cell that get internalized from the plasma membrane. The color code indicates the signaling activity of the receptor. Credit: MPI f. Molecular Physiology
Pinpointing positions of individual molecules while also measuring their activity and interactions in the same living cell is now possible. A dedicated cooling protocol on a microscope allows to pause cellular life at subzero temperatures, to let it continue to live again after warming...
Read More
Recent Comments