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    cryo-electron microscopy tagged posts

    Long-sought Structure of Telomerase Paves way for New Drugs for Aging, Cancer

    April 26, 2018, Categories  Biology/Biotechnology, Health/Medical

    Shown is the space-filling model of human telomerase holoenzyme structure determined by cryo-electron microscopy (cryo-EM). Telomerase catalyzes the synthesis of telomeric DNA (green) at the ends of chromosomes (blue) to compensate for the loss of telomeres during genome replication. The structure comprises two lobes with distinct functionalities: the catalytic core (purple) responsible for DNA synthesis and an H/ACA ribonucleoprotein lobe (cyan, teal and light green) important for telomerase biogenesis and localization to the Cajal body (red dots and lower left in closeup). Given that telomerase regulation is implicated in cancer and aging, this first architectural visualization of human telomerase represents an important breakthrough in the telomerase field and telomerase-based therapeutic design. Credit: Janet Iwasa

    Shown is the space-filling model of human telomerase holoenzyme structure determined by cryo-electron microscopy (cryo-EM). Telomerase catalyzes the synthesis of telomeric DNA (green) at the ends of chromosomes (blue) to compensate for the loss of telomeres during genome replication. The structure comprises two lobes with distinct functionalities: the catalytic core (purple) responsible for DNA synthesis and an H/ACA ribonucleoprotein lobe (cyan, teal and light green) important for telomerase biogenesis and localization to the Cajal body (red dots and lower left in closeup)...

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    Sharpest Image of Alzheimer’s Fibrils shows previously unknown details

    September 10, 2017, Categories  Biology/Biotechnology, Health/Medical

    Science: Sharpest image of Alzheimer's fibrils shows previously unknown details

    A cross section through the fibril illustrating the stepwise overlapping arrangement of the Aβ proteins Credit: Forschungszentrum Jülich / HHU Düsseldorf / Gunnar Schröder

    A team from Germany and the Netherlands has determined the structure of an amyloid fibril with previously unachieved resolution. The fibrils of the body’s own amyloid beta (Aβ) protein are the main constituent of brain protein deposits associated with Alzheimer’s. The atomic-level 3D structure elucidated by the scientists reveals previously unknown aspects of the growth of harmful deposits and the effect of genetic risk factors.

    The structure reveals how the many single Aβ protein molecules are staggered in layers on top of each other and are arranged into protofilaments...

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    Zika virus Structure revealed, a critical advance in the development of Treatments & Vaccines

    March 31, 2016, Categories  Biology/Biotechnology, Health/Medical

    A representation of the surface of the Zika virus is shown. A team led by Purdue University researchers is the first to determine the structure of the Zika virus, which reveals insights critical to the development of effective antiviral treatments and vaccines. Credit: Purdue University image/courtesy of Kuhn and Rossmann research groups

    A representation of the surface of the Zika virus is shown. A team led by Purdue University researchers is the first to determine the structure of the Zika virus, which reveals insights critical to the development of effective antiviral treatments and vaccines. Credit: Purdue University image/courtesy of Kuhn and Rossmann research groups

    The Purdue Uni team also identified regions within the Zika virus structure where it differs from other flaviviruses, the family of viruses to which Zika belongs that includes dengue, West Nile, yellow fever, Japanese encephalitis and tick-borne encephalitic viruses...

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