CXCR4 is a receptor broadly expressed in cells of immune and the central nervous systems and can mediate migration of resting leukocytes and haematopoietic progenitors. It is also used by strains of HIV1 to gain entry into Helper T cells, and are typically detected at the later stages, associated with a rapid decline in CD4+ T cells and progression to AIDS.
They disabled a T-cell surface protein CXCR4, exploited by HIV when the virus infects T cells and causes AIDS. The group also successfully shut down PD-1, a protein that has attracted intense interest in the burgeoning field of cancer immunotherapy, as scientists have shown that using drugs to block PD-1 coaxes T cells to attack tumors.
T cells not only stand at the center of many disease processes, but could be easily gathered from pat...
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