cystatins tagged posts

ERβ-mediated induction of cystatins results in suppression of TGFβ signaling and inhibition of triple-negative breast cancer metastasis. Proceedings of the National Academy of Sciences, 2018; 201807751 DOI: 10.1073/pnas.1807751115

Mayo Clinic researchers have identified the drug estradiol as a potential new treatment for a subset of women with triple-negative breast cancer. Their findings are published in the Proceedings of the National Academy of Sciences.

“Triple-negative breast cancer is a form of breast cancer that lacks expression of estrogen receptor alpha, progesterone receptor, and human epidermal growth factor receptor 2, also known as HER2. And it exhibits high rates of disease recurrence,” says John Hawse, Ph.D., a molecular biologist at Mayo Clinic and senior author...