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Molecular ‘Switch’ Reverses Chronic Inflammation and Aging

A molecular modeling image showing the detector portion of the NLRP3 inflammasome in red, magenta, and yellow
The NLRP3 receptor protein is responsible for detecting potential pathogens in the body and launching an immune response. (Image by MLGProGamer123 via Wikimedia Commons)

Chronic inflammation, which results when old age, stress or environmental toxins keep the body’s immune system in overdrive, can contribute to a variety of devastating diseases, from Alzheimer’s and Parkinson’s to diabetes and cancer.

Now, scientists at the University of California, Berkeley, have identified a molecular “switch” that controls the immune machinery responsible for chronic inflammation in the body. The finding, which appears online Feb. 6 in the journal Cell Metabolism, could lead to new ways to halt or even reverse many of these age-related conditions.

“My lab is very interested in unde...

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