A new study in mice reveals that increased body weight and high blood sugar as a result of consuming a high-fat diet may cause anxiety and depressive symptoms and measurable changes in the brain.
Also, the beneficial effects of an antidepressant were blunted in mice fed a high-fat diet. “When treating depression, in general there is no predictor of treatment resistance,” said Dr. Bruno Guiard, senior author of the British Journal of Pharmacology study. “So if we consider metabolic disorders as a putative treatment resistance predictor, this should encourage psychiatrists to put in place a personalized treatment with antidepressant drugs that do not further destabilize metabolism.”
On the other hand, taking mice off a high-fat diet completely reversed the animals’ metabolic impairments ...
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