A set of neurons identified by Scripps Research scientists influence the start of eating and drinking. Do you grab a fork and take a first bite of cake, or say no and walk away? Our motivation to eat is driven by a complex web of cells in the brain that use signals from within the body, as well as sensory information about the food in front of us, to determine our behaviors. Now, Scripps Research scientists have identified a group of neurons in a small and understudied region of the brain — the parasubthalamic nucleus (PSTN) — that controls when an animal decides to take a first bite of food.
In the study, published in Molecular Psychiatry on July 4, 2024, the team of scientists set out to selectively manipulate a group of PSTN cells that dial up their activity during periods of bi...
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