Dendritic cell vaccine tagged posts

Two images of EVIR-engineered dendritic cells (green) capturing tumor antigens in exosomes (gold/red). Cell nuclei are colored blue. Credit: C. Cianciaruso/M. De Palma/EPFL

Researchers at EPFL have created artificial molecules that can help the immune system to recognize and attack cancer tumors. Immunotherapies are breakthrough treatments that stimulate the patient’s immune cells to attack the tumor through the recognition of tumor antigens. They can be very effective, but currently can only cure a minority of patients with solid tumors. Researchers and physicians are now looking into ways of increasing the precision and strength of the immune attack on the tumor.

One approach is the “dendritic cell vaccine...

Brain scans are from glioblastoma trial from manuscript. Credit: Clinical Cancer Research/American Association for Cancer Research

Dendritic cell vaccine supports further study in larger trials. A phase 1 study of 11 patients with glioblastoma who received injections of an investigational vaccine therapy and an approved chemotherapy showed the combination to be well tolerated while also resulting in unexpectedly significant survival increases, researchers at the Duke Cancer Institute report. Patients treated with the study drug (dose-intensified temozolomide and vaccines) were continuously monitored for toxicity and adverse events. Study patients experienced known side effects with temozolomide, including nausea, lymphopenia, thrombocytopenia and fatigue.

There were no treatment limiting a...