In certain settings, the TGF-beta pathway can act as an oncogene, enhancing cancer progression in humans. The activation of this pathway can increase the growth of tumors by promoting cell invasion, activating cancer stem cells, and in some cases, promoting the spread of cancer. In recent years, a number of deubiquitinating enzymes have been shown to regulate the TGF-β pathway and may potentially be considered as a new class of drug targets...
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