diabetes tagged posts

Blood vessel-on-a-chips show anti-cancer drug effects in human cells. Credit: 2018 YUKIKO MATSUNAGA, INSTITUTE OF INDUSTRIAL SCIENCE, THE UNIVERSITY OF TOKYO

Researchers at the Institute of Industrial Science (IIS), the University of Tokyo, CNRS and INSERM, report a new organ-on-a-chip technology for the study of blood vessel formation and drugs targeting this event. The technology recreates a human blood vessel and shows how new capillaries grow from a single vessel (parent vessel) in response to proper biochemical signaling cues. The technology can further be used to develop drugs targeting this growth as a therapeutic approach to treat cancer and blood-vessel-related diseases. The study can be read in EBioMedicine.

Angiogenesis describes a specific process of blood vessel formation from...

3-4 cups of Coffee a day linked to Longer Life

Three or 4 cups a day confers greatest benefit, except in pregnancy and for women at risk of fracture. Drinking coffee is “more likely to benefit health than to harm it” for a range of health outcomes, say researchers in The BMJ today. They bring together evidence from over 200 studies and find that drinking 3 to 4 cups of coffee a day is associated with a lower risk of death and getting heart disease compared with drinking no coffee. Coffee drinking is also associated with lower risk of some cancers, diabetes, liver disease and dementia.

However, they say drinking coffee in pregnancy may be associated with harms, and may be linked to a very small increased risk of fracture in women...

Highlights
•Plasma TMAO levels are elevated in type 2 diabetic patients
•Levels of the TMAO-producing enzyme FMO3 in adipose tissue correlate with obesity
•Pharmacologic and genetic inhibition of Fmo3 stimulates white adipose tissue beiging
•Inhibition of Fmo3 promotes resistance to obesity

Cleveland Clinic researchers showed that blocking a specific intestinal microbial pathway can prevent obesity and insulin resistance, as well as cause fat tissue to become more metabolically active. The team, led by J. Mark Brown, Ph.D...

Efficient miR-92a downregulation in the skin upon treatment with caged antimiR-92a.

MicroRNAs are interesting target structures for new therapeutic agents. They can be blocked through synthetic antimiRs. However, to date it was not possible to use these only locally. Researchers at Goethe University Frankfurt have now successfully achieved this in the treatment of impaired wound healing with the help of light-inducible antimiRs.

MicroRNAs are small gene fragments which bond onto target structures in cells and in this way prevent certain proteins from forming. As they play a key role in the occurrence and manifestation of various diseases, researchers have developed what are known as antimiRs, which block microRNA function...