diabetes tagged posts

Pocket-sized Retina Camera, no Dilating Required

It’s the part of the eye exam everyone hates: the pupil-dilating eye drops. The drops work by opening the pupil and preventing the iris from constricting in response to light and are often used for routine examination and photography of the back of the eye. The drops sting, can take up to 30 minutes to work, and cause blurry vision for several hours afterwards. Now, University of Illinois at Chicago College of Medicine and Massachusetts Eye and Ear/Harvard Medical School researchers have developed a cheap, portable camera that can photograph the retina without the need for pupil-dilating eye drops. Made out of simple parts mostly available online, the camera’s total cost is about $185.

“As residents seeing patients in the hospital, there are...

Postprandial macrophage-derived IL-1β stimulates insulin and both synergistically promote glucose disposal and inflammation. Nature Immunology, January 2017 DOI: 10.1038/ni.3659

When we eat, we do not just take in nutrients – we also consume a significant quantity of bacteria. The body is faced with the challenge of simultaneously distributing the ingested glucose and fighting these bacteria. This triggers an inflammatory response that activates the immune systems of healthy individuals and has a protective effect, as doctors from the University and the University Hospital Basel have proven for the first time. In overweight individuals, however, this inflammatory response fails so dramatically that it can lead to diabetes.

It is well known that type 2 diabetes (or adult-onset diabetes) le...

High-resolution model of six insulin molecules assembled in a hexamer. Credit: Isaac Yonemoto/Wikipedia

NZ researchers have uncovered a new mechanism that controls the release of insulin in the body, providing hope for those with a genetic susceptibility to type 2 diabetes. The findings show for the first time that a protein, beta catenin is crucial for controlling the release of insulin from the pancreas to maintain stable blood sugar levels. They focused on a variant in a gene called TCF7L2. This variant has been known to science for about 10 years and is the biggest contributing factor for whether people are genetically susceptible to getting type 2 diabetes or not.

“We wanted to understand what happens in the body’s cells that are associated with TCF7L2 and how the processes that go on...

Highlights •The ER stress sensor IRE-1 has a distinct function in cytoplasmic homeostasis •Local redox signals block IRE-1 ER signaling by sulfenylating a kinase cysteine •This functional switch initiates the p38/SKN-1(Nrf2) antioxidant response at IRE-1 •The IRE-1 paradigm implies broad and versatile functions for signaling at cysteines

Reactive oxygen species (ROS) sometimes can aid in maintaining health – findings now boosted by a surprising discovery from the researchers. In other circumstances, high levels of reactive forms of oxygen can damage proteins and contribute to diabetic complications and many other diseases.

Led by Keith Blackwell, M.D., Ph.D...