Lack of antinociceptive tolerance of YHS (200 mg/kg) in the tail flick assay (n = 7–8).
Root extracts from the flowering herbal plant Corydalis yanhusuo, or YHS, has widely used for centuries as a pain treatment. Yet few studies have investigated how it works on different forms of pain, and little is known about its molecular mechanisms. In a new study, Olivier Civelli, professor and chair of pharmacology at the University of California, Irvine et al show how YHS effectively treats different forms of pain. Most notably it can reduce chronic neuropathic pain which is poorly treated with common medicines. They also show that YHS seems to not lose its potency over time, as happens with many analgesics.
The researchers analyzed YHS pain relief properties in mouse tests that monitor acute, pe...
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