driver of non-alcoholic steatohepatitis (NASH) tagged posts

This is a liver section that shows liver fibrosis revealed by staining of collagen accumulation in a mouse with human like NASH.
Credit: UC San Diego Health

Researchers identify enzyme as responsible for onset and progression of fatty liver disease in mice and human clinical specimens. Researchers at University of California San Diego School of Medicine have discovered using mice and human clinical specimens, that caspase-2, a protein-cleaving enzyme, is a critical driver of non-alcoholic steatohepatitis (NASH), a chronic and aggressive liver condition. By identifying caspase-2’s critical role, they believe an inhibitor of this enzyme could provide an effective way to stop the pathogenic progression that leads to NASH — and possibly even reverse early symptoms.

The findings are published in...