Drug therapy tagged posts

Potential New Therapy for Liver Diseases

illustration of diseased liver
Mechanical Stretch Increases Expression of CXCL1 in Liver Sinusoidal Endothelial Cells to Recruit Neutrophils, Generate Sinusoidal Microthombi, and Promote Portal HypertensionGastroenterology, 2019; DOI: 10.1053/j.gastro.2019.03.013

Drug therapy may effectively treat a potentially life-threatening condition associated with cirrhosis and other chronic liver diseases, according to a new study by Mayo Clinic researchers. The study was posted in March on Gastroenterology, the online journal of the American Gastroenterological Association. Print publication is scheduled for July.

While therapies have been available to treat some forms of liver disease, including hepatitis C and autoimmune hepatitis, options have been more limited for treating portal hypertension, a condition where th...

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Opposite effect: Protein widely known to Fight Tumors also Boosts Cancer Growth

UC San Diego researchers found that the PUMA protein works inside the cell’s mitochondria to switch energy production processes and stimulate cancer growth.
Credit: Xu Lab, UC San Diego

Researchers find evidence that genome ‘guardian’ can stimulate cancer. Researchers studying p53, the heralded cancer-fighting ‘guardian of the genome,’ found that the human protein also plays a role in promoting tumors, in addition to suppressing them. They found that the PUMA protein works inside the cell’s mitochondria to switch energy production processes and stimulate cancer growth. Search for a description of “p53” and it becomes clear that this human protein is widely known for its cancer-fighting benefits, leading to its renown as “the guardian of the genome.”

Scientists at the University of Ca...

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