Formation and function of microRNAs
A tiny RNA appears to play a role in producing major depression, the mental disorder that affects as many as 250 million people a year worldwide. Major depression, formally known as major depressive disorder, or MDD, brings increased risk of suicide and is reported to cause the second-most years of disability after low-back pain.
MicroRNA levels are significantly elevated in the brains of experimental rats with induced depression from corticosterone treatment, in the post-death brains of humans diagnosed with MDD and in peripheral blood serum from living patients with MDD, according to a study by led by Prof Yogesh Dwivedi, Ph.D.
This microRNA—miR-124-3p—is thus a potential therapeutic target for novel drug development, and it can serve as a putative bio...
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