eGFR tagged posts

Clinical trial shows constipation drug can treat patients with chronic kidney disease

World's first clinical trial showing lubiprostone aids kidney function
Administering lubiprostone alters gut microbiota, leading to improved mitochondrial function and suppression of inflammation. This improved renal function by increasing the levels of aguA and polyamines. Credit: Shun Watanabe

Chronic kidney disease (CKD) is a major health issue worldwide. Many patients end up requiring regular dialysis to avoid kidney failure and stay alive. Despite the severity of the condition, there are currently no drugs available that improve kidney function.

A research group led by Tohoku University Graduate School of Medicine’s Professor Takaaki Abe has found a remarkable solution to treat patients with CKD by co-opting a drug typically used for constipation...

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