At the level of gene expression, PGC-1α is sensitive to numerous signaling cascades, most pronounced of which is the cAMP signaling pathway
Although both exercises activate PGC-1α gene (peroxisome proliferator-activated receptor-gamma coactivator), the adaptation processes stimulated are not the same and depend on the type of exercise.
Proteins run the body: They turn processes on or off or speed them up or slow them down. The body has many different proteins, and the instructions to make them are written on sections of DNA, referred to as genes. Different genes code for different proteins, but different proteins can also come from the same gene. Called isoforms, these proteins are produced when only part of the gene’s code is read.
The PGC-1α protein turns on other genes...
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