engineered T cells tagged posts

This is a schematic of how a “chimeric autoantibody receptor,” or CAAR, that displays fragments of the autoantigen Dsg3 helps fight an autoimmune disease called pemphigus vulgaris, a condition in which a patient’s own immune cells attack Dsg3, which normally adheres skin cells. Credit: Christoph T. Ellebrecht, MD, Perelman School of Medicine, University of Pennsylvania

Preclinical study shows that engineered T cells can selectively target the antibody-producing cells that cause autoimmune disease. The autoimmune disease the team studied is pemphigus vulgaris (PV), a condition in which a patient’s own immune cells attack a protein called desmoglein-3 (Dsg3) that normally adheres skin cells...

Engineering T cells to treat pancreatic cancer Researchers hope to have a human version of the T cell in clinical trials this year

Hingorani, a pancreatic cancer specialist, teamed up with Fred Hutch immunotherapy experts Drs. Phil Greenberg and Ingunn Stromnes in successful efforts to breach the cancer’s physical and immunological walls using immunotherapy, a type of treatment that harnesses or refines the body’s own immune system with T-cells engineered to recognize and destroy cancer cells.

Specifically, Hingorani’s team created T cells with a high ffinity to a “relatively” tumor-specific antigen. Why relatively? Notoriously difficult pancreatic tumor cells don’t produce many unique proteins that allow for completely tumor-specific T cells...