Mice were exposed to two auditory fear conditioning, separated by five hours. Both memories were encoded by shared neurons in the lateral amygdala while they were encoded by different neurons in the auditory cortex. Mice showed freezing behavior in response to 7kHz and 2kHz tones. Induction of optical long term depotentiation (LTD) to synapses specific to 7kHz fear memory, erased only that memory (test 3) without affecting the other memory (test 4) that was stored in shared neuron ensemble.
Credit: Kaoru Inokuchi, Kareem Abdou
Memories are formed through long-term changes in synaptic efficacy, a process known as synaptic plasticity, and are stored in the brain in specific neuronal ensembles called engram cells, which are activated during corresponding events...
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