entorhinal cortex (EC) tagged posts

This is a grid cell from the entorhinal cortex (EC) of the mouse brain, firing repeatedly and uniformly in a grid-like pattern. When a mouse moves through its environment, grid cells are activated, with each cell representing a specific location. This creates a triangular coordinate system that allows for spatial navigation. Several grid cells create a triangular coordinate system that allows for spatial navigation. The accumulation of tau protein in the brain of a mouse model of Alzheimer’s disease was shown to disrupt the function of grid cells, causing problems with navigation. The findings explains why Alzheimer’s patients tend to wander and get lost. Credit: Lab of Karen Duff, PhD, Columbia University Medical Center