Highlights •Partial reprogramming erases cellular markers of aging in mouse and human cells •Induction of OSKM in progeria mice ameliorates signs of aging and extends lifespan •In vivo reprogramming improves regeneration in 12-month-old wild-type mice
In mice carrying a mutation leading to premature aging, reprogramming of chemical marks in the genome, ie epigenetic marks, reduced many signs of aging in the mice and extended their lifespan on average from 18 weeks to 24. The study suggests epigenetic changes drive the aging process, and that those changes may be malleable. “We did not correct the mutation that causes premature aging in these mice,” says Juan Carlos Izpisua Belmonte, a professor in the Salk Institute of Biological Science’s Gene Expression Laboratory...
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