epilepsy tagged posts

A new Salk study is the first to closely follow the development of new neurons in the adult brain, giving insight into neurodevelopmental disorders such as autism and schizophrenia. By genetically engineering new neurons to fluoresce green, researchers were able to see when the new cells grew and branched surrounded by other cell nuclei (blue) in the brain. Credit: Salk Institute

A new study is first to closely follow development of new neurons in the adult brain, giving potential new insight into neurodevelopmental disorders such as autism and schizophrenia. New brain cells began with a period of overgrowth, sending out a plethora of neuronal branches, before the brain pruned back the connections. “We were surprised by the extent of the pruning we saw,” says Prof. Rusty Gage.

While most o...

The N3A receptor, as modeled here by the UB researchers, may be silent under normal conditions, but can be reactivated through the unique site (in red) under acidic conditions, such as after a stroke or seizure.

Strokes, seizures, traumatic brain injury and schizophrenia: these conditions can cause persistent, widespread acidity around neurons in the brain. But exactly how that acidity affects brain function isn’t well understood. University at Buffalo researchers have begun to unravel some of the puzzle. They found that an elusive brain receptor may play an important role in the death of neurons from neurological diseases.

The UB researchers study a family of brain receptors that are critical to learning and memory, called NMDA (N-methyl-D-aspartate) receptors...