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    estrogen-related receptor gamma (ERR ɣ) tagged posts

    The Protein that Keeps the Pancreas from Digesting itself

    April 22, 2022, Categories  Biology/Biotechnology, Health/Medical

    Left: Acinar cells (red) in a healthy pancreas. Right: Extensive pancreatic scarring (purple) when ERR gamma is lost from acinar cells.
    Click here for a high-resolution image.
    Credit: Salk Institute

    Potential new therapeutic target for pancreatitis and pancreatic cancer. Now, Salk scientists report in the journal Gastroenterology on April 21, 2022, that a protein known as estrogen-related receptor gamma (ERR ɣ) is critical for preventing pancreatic auto-digestion in mice. Moreover, they discovered that people with pancreatitis have lower levels of ERR ɣ in cells affected by this inflammation.

    These findings suggest that new therapies aimed at regulating ERR ɣ activity could help prevent or treat pancreatitis and pancreatic cancer.

    “Our finding provides new insight into both the ...

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