Killer T cells surround a cancer cell. Credit: NIH
An international team discovered how a shift to increased fat utilization is required for the development and growth of lymphatic vessels for metastasis. This discovery paves the way towards developing therapeutics to limit lymphatic vessel growth in cancer by targeting fat utilization. Formation of new lymphatic vessels, ie lymphangiogenesis, is a poorly understood process, which currently lacks clinically approved drugs to prevent their growth during disease.
The study began with a simple observation: lymphatics use more fatty acids compared to blood vessels. This is the first description of the nutrient utilization of lymphatic vessels...
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