fibrin tagged posts

Human and animal study offers insight into treating periodontal disease and other inflammatory disorders. Blocking function of a blood-clotting protein prevented bone loss from periodontal (gum) disease in mice, according to research led by scientists at the National Institute of Dental and Craniofacial Research (NIDCR), part of the National Institutes of Health. Drawing on animal and human data, the researchers found that buildup of the protein, called fibrin, triggers an overactive immune response that damages the gums and underlying bone...

Cartilage template formation via engineered extracellular matrix. Credit: Syam Nukavarapu/UConn Photo

A team of UConn Health researchers has designed a novel, hybrid hydrogel system to help address some of the challenges in repairing bone in the event of injury. There are over 200 bones in an adult human skeleton, ranging in size from a couple of millimeters in length to well over a foot. How these bones form and how they are repaired if injured varies, and has posed a challenge for many researchers in the field of regenerative medicine.

Two processes involved with human skeletal development help all the bones in our body form and grow. These processes are called intramembranous and endochondral ossification, IO and EO respectively...

Fibri(nogen) drives repair after acetaminophen-induced liver injury via leukocyte αMβ2 integrin-dependent upregulation of MMP12

A team of MSU researchers has uncovered a new pathway in the body that stimulates liver repair. Using an experimental model of high-dosage acetaminophen, the team found that liver injury activated blood clotting, which then stimulated liver repair. Acetaminophen is the active ingredient in more than 600 medications and is a leading cause of drug-induced liver failure in the United States if used above the recommended dosage.

“This pathway of repair has never been described before and could lead to new strategies to promote liver repair,” said Luyendyk, an associate professor of pathobiology and diagnostic investigation...

This is a coronary artery structure being 3-D bioprinted. Credit: Carnegie Mellon University College of Engineering

This month >4,000 Americans are on waiting list to receive a heart transplant. Researchers have used a new 3D bioprinting method to bioprint models of hearts, arteries, bones and brains out of biological materials. The work could one day lead to a world in which transplants are no longer necessary to repair damaged organs.

“We’ve been able to take MRI images of coronary arteries and 3D images of embryonic hearts and 3D bioprint them with unprecedented resolution and quality out of very soft materials like collagens, alginates and fibrins,” said Assoc Prof Adam Feinberg

“3-D printing of various materials has been a common trend in tissue engineering in the last decade, but unt...