Numerous epidemiological studies have revealed profitable effects of dietary intake of especially fish oil on cognitive decline during aging and dementia. One of the invariable pathologies in AD is degeneration of cholinergic synapses in brain cortex and hippocampus. Current pharmacological interventions are limited to a few drugs that alleviate symptoms but do not slow down the underlying disease processes eg inhibitors of cholinesterases, enzymes that degrade the neurotransmitter acetylcholine, or memantine, a modulator of glutamate neurotransmission.
Within the EU-funded project LipiDiDiet (FP7-211696, the...
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