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A stress-related chemical could initiate symptoms of depression

A stress-related chemical could initiate symptoms of depression
Excitatory neurotransmitter-Glu induces active FA generation in the mitochondria. Credit: Molecular Psychiatry (2025). DOI: 10.1038/s41380-025-03405-2

Depression, one of the most prevalent mental health disorders worldwide, is characterized by persistent feelings of sadness, impaired daily functioning and a loss of interest in daily activities, often along with altered sleeping and eating patterns. Past research findings suggest that stress can play a key role in the emergence of depressive symptoms, yet the biological processes via which it might increase the risk of depression remain poorly understood.

Researchers at Wenzhou Medical University, Capital Medical University and other institutes in China recently carried out a study investigating the biological processes that could ...

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Could Interstellar Ice provide the Answer to Birth of DNA?

The building blocks of DNA could have come from space

The building blocks of DNA could have come from space

Researchers at the University of York have shown that molecules brought to earth in meteorite strikes could potentially be converted into the building blocks of DNA. They found that organic compounds, amino nitriles, the molecular precursors to amino acids, were able to use molecules present in interstellar ice to trigger the formation of the backbone molecule, 2-deoxy-D-ribose, of DNA. It has long been assumed that amino acids were present on earth before DNA, and may have been responsible for the formation of one of the building blocks of DNA, but this new research throws fresh doubt on this theory.

Dr Paul Clarke, from the University of York’s Department of Chemistry, said: “The origin of important biological molecules is one of the ...

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