This graphical abstract depicts the findings of Jang et al., which show that it is actually the small intestine that clears most dietary fructose, and this is enhanced by feeding. High fructose doses spill over to the liver and to the colonic microbiota for metabolism.
Princeton University researchers report that in mice, fructose, a sugar found in fruit, is processed mainly in the small intestine, not in the liver as had previously been suspected. Sugary drinks and processed high-sugar foods overwhelm the small intestine and spill into the liver for processing. Additionally, the authors learned that the ability of the small intestine to process fructose is higher after a meal. The work appears February 6 in the journal Cell Metabolism.
Evidence from previous animal and human studies has s...
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