FXR tagged posts

Beneficial gut microbes and the body work together to fine-tune fat metabolism and cholesterol levels, according to a new preclinical study by investigators from Weill Cornell Medicine and the Boyce Thompson Institute at Cornell University’s Ithaca campus.

The research is published in the journal Nature.

The human body has co-evolved with the beneficial microbes that live in the gut (termed the microbiota), resulting in mutually favorable relationships that aid in the d...

Microbes living in our guts help us digest food by reshaping the bile acids that our livers produce for breaking down fats. It turns out that two of these microbially-modified bile acids may affect our risk—in opposite directions—for developing colon cancer.

The link between these bile acids and colon cancer risk was recently uncovered as University of Wisconsin–Madison scientists sought to better understand the relationship between gut microbes and our bodies.

In many ways, that relationship revolves around a specific protein called the farnesoid X receptor, or FXR, which helps maintain a healthy gut through its intimate relationship with bile acids...