Model for the regulation of visceral fat ER stress in obesity. Induction of TRIP-Br2 and GATA3 during obesity via ER stress is critical for the visceral fat proinflammatory responses.
Researchers have long-known that visceral fat (which wraps around the internal organs) is more dangerous than subcutaneous fat (under the skin). But how visceral fat contributes to insulin resistance and inflammation has remained unknown. A study points blame at a regulatory molecule in cells called TRIP-Br2 that is produced in response to overeating’s stress on the machinery cells use to produce proteins.
In previous studies, in obese humans TRIP-Br2 was turned-up in visceral fat but not in subcutaneous fat...
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