GFRAL-expressing neurons (yellow cells) are found exclusively in the brainstem (pictured), and form the ’emergency circuit’ of body weight regulation. Credit: NGM Bio
Insights enable the discovery of multiple drug candidates for obesity and cachexia. Scientists at NGM Bio have revealed deep insights into the role that a little-understood human hormone plays in regulating body weight. Named Growth and Differentiation Factor 15 (GDF15), this hormone is typically active only when the body experiences acute or prolonged stress, including following exposure to tissue-damaging toxins, such as chemotherapy, or during chronic disease, such as obesity or cancer...
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