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    Scientists develop Gene Silencing DNA Enzyme that can Target a Single Molecule

    May 9, 2023, Categories  Biology/Biotechnology, Health/Medical

    UC Irvine scientists develop gene silencing DNA enzyme that can target a single molecule
    “The gene silencing Dz 46 enzyme we developed through chemical engineering has the ability to distinguish and cut a single point mutation in an RNA strand,” says John Chaput, UCI professor of pharmaceutical sciences and corresponding author. “When you are talking about precision medicine for patients, it doesn’t get more precise than that.” Steve Zylius / UCI

    Researchers from the University of California, Irvine have developed a DNA enzyme—or DNAzyme—that can distinguish between two RNA strands inside a cell and cut the disease-associated strand while leaving the healthy strand intact. This breakthrough “gene silencing” technology could revolutionize the development of DNAzymes for treating cancer, infectious diseases and neurological disorders.

    DNAzymes are nucleic ac...

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