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    These 11 Genes may help us Better Understand Forever Chemicals’ Effects on the Brain

    January 9, 2025, Categories  Chemistry/Nanotechnology, Health/Medical

    A blue gloved hand places a small bottle of liquid into a laboratory machine.
    A study led by the labs of University at Buffalo chemistry professors G. Ekin Atilla-Gokcumen and Diana Aga has uncovered some molecular clues about the neurotoxic effects of  per- and polyfluorinated alkyl substances, better known as forever chemicals. Photo: Meredith Forrest Kulwicki/University at Buffalo

    Molecular clues about the neurotoxic effects of PFAS. A new study has identified 11 genes that may hold the key to understanding the brain’s response to these pervasive chemicals commonly found in everyday items.

    Per- and polyfluorinated alkyl substances (PFAS) earn their “forever chemical” moniker by persisting in water, soil and even the human brain.

    This unique ability to cross the blood-brain barrier and accumulate in brain tissue makes PFAS particularly concerning, but t...

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    Learning and Staying in Shape key to Longer Lifespan, study finds

    October 14, 2017, Categories  Biology/Biotechnology, Health/Medical

    Age-specific and sex-specific effects of the 4 GWS associations in LifeGen and the validated candidate loci. The four GWS and three suggestive replicated loci were analysed for age-specific and sex-specific effects on lifespan. a The variants at APOE and CHRNA3/5 exhibit sexually dimorphic effects on parental mortality, while all other variants exhibit more modest often non-significant sex-specific differences. b The effects of each gene on male and female lifespan were meta-analysed and studied in the cases that died aged between 40 and 75 or after 75. APOE exerts a much greater effect in the older age group, while most of the other genes exhibit the opposite effect. FOXO3 appears neutral, if not positive, in the earlier age group. c Effects on mortality were studied in both age groups for both sexes. APOE has the strongest effect on females aged 75+, CHRNA3/5 acts on males aged 40−75 and all other genes display more ambiguous trends

    Age-specific and sex-specific effects of the 4 GWS associations in LifeGen and the validated candidate loci. The four GWS and three suggestive replicated loci were analysed for age-specific and sex-specific effects on lifespan. a The variants at APOE and CHRNA3/5 exhibit sexually dimorphic effects on parental mortality, while all other variants exhibit more modest often non-significant sex-specific differences. b The effects of each gene on male and female lifespan were meta-analysed and studied in the cases that died aged between 40 and 75 or after 75. APOE exerts a much greater effect in the older age group, while most of the other genes exhibit the opposite effect. FOXO3 appears neutral, if not positive, in the earlier age group...

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