Proliferation of NSCs and expression of Shh in Gli1-null mice.
An experimental drug GANT61 originally identified in a National Cancer Institute library of chemical compounds as a potential therapy for brain and basal cell cancers improves the symptoms of mice with a form of the debilitating neurological disorder multiple sclerosis (MS), according to new research.
It blocks the action of a key protein, Gli1, which is involved in so-called sonic hedgehog signaling, a biological pathway closely tied to neural stem cell development and the growth of some cancers, and whose signaling is raised in tissue samples taken from brain lesions in patients with MS.
In the study, mice with chemically damaged brain myelin were given daily doses of GANT61 for one month...
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