glioblastoma tagged posts

Researchers at the University of Notre Dame have developed a novel, automated device capable of diagnosing glioblastoma, a fast-growing and incurable brain cancer, in less than an hour. The average glioblastoma patient survives 12–18 months after diagnosis.

The crux of the diagnostic is a biochip that uses electrokinetic technology to detect biomarkers, or active Epidermal Growth Factor Receptors (EGFRs), which are overexpressed in certain cancers such as glioblastoma and found in extracellular vesicles.

“Extracellular vesicles or exosomes are unique nanoparticles secreted by cells...

Immunotherapy combo that encourages immune cells to consume tumors could lead to long-term remission for glioblastoma. A combination of immunotherapy agents that encourages some immune cells to eat cancer cells and alert others to attack tumors put mice with a deadly type of brain cancer called glioblastoma into long-term remission, a new study led by UT Southwestern scientists suggests. The finding, published online March 20, 2020, in Nature Communications, could lead to new therapies that may significantly extend survival for human glioblastoma patients, which stands at an average of 15 months after diagnosis even with current state-of-the-art therapies.

The immune system has two branches: innate immunity, an evolutionarily older system that continually scans the b...

Chase Cornelison is a post-doctoral researcher at Virginia Tech and lead author of an article published in Scientific Reports that details a solution to stopping the spread of glioblastoma in the brain.

A team of researchers may have found a solution to stopping the spread of glioblastoma with a new drug and cancer treatment method. In people who have glioblastoma, the deadliest form of brain cancer, this fluid has a much higher pressure, causing it to move fast and forcing cancer cells to spread. And a common cancer therapy, which inserts a drug directly into the tumor with a catheter, can make this fluid move even faster.

A team of researchers at Virginia Tech, led by Jennifer Munson, an assistant professor in the Department of Biomedical Engineering and Mechanics in the College of Engin...

Researchers at Duke Cancer Institute have tracked the missing T-cells in glioblastoma patients in the bone marrow, locked away and unable to function because of a process the brain stimulates in response to glioblastoma, to other tumors that metastasize in the brain and even to injury.
Credit: Alisa Weigandt for Duke Health

A mysterious lack of T-cells has hindered the immune system’s ability to fight glioblastoma. Researchers have tracked the missing T-cells in glioblastoma patients. They found them in abundance in the bone marrow, locked away and unable to function because of a process the brain stimulates in response to glioblastoma, to other tumors that metastasize in the brain and even to injury.

Glioblastoma brain tumors can have an unusual effect on the body’s immune system, often ca...