Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease
Scientists have developed a ‘smart’ drug that safely clears the liver of fat and prevents blood vessels from clogging up. Liver-specific delivery of the thyroid hormone T3 using glucagon corrects obesity, glucose intolerance, fatty liver disease and atherosclerosis without causing adverse effects in other tissues. “While the ability of T3 to lower cholesterol is known for centuries, deleterious effects, in particular on the skeleton and the cardiovascular system, do so far limit its medicinal utility,” says Brian Finan.
The constant rise in obesity and diabetes represents a major burden of our society...
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