GluD tagged posts

A “dormant” brain protein turns out to be a powerful switch

Delta-type ionotropic glutamate receptors, or GluDs, are made of four GluD protein subunits that make a single receptor. The blue is D-serine, which is the neurotransmitter that activates the receptor
Delta-type ionotropic glutamate receptors, or GluDs, are made of four GluD protein subunits that make a single receptor. The blue is D-serine, which is the neurotransmitter that activates the receptor. Credit: Edward Twomey, Ph.D.

Researchers at Johns Hopkins Medicine report that they have uncovered a promising drug target that could allow scientists to increase or decrease the activity of specific brain proteins. The discovery may lead to new treatments for psychiatric conditions such as anxiety and schizophrenia, as well as a neurological disorder that affects movement and balance. The work was supported by funding from the National Institutes of Health.

The proteins at the center of the research are known as delta-type ionotropic glutamate receptors, or GluDs...

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