The response we’ve seen in flies to low doses of lithium is very encouraging and our next step is to look at targeting GSK-3 in more complex animals with the aim of eventually developing a drug regime to test in humans.
Fruit flies live 16% longer than average when given low doses of the mood stabiliser lithium, according to a UCL-led study. How lithium stabilises mood is poorly understood but when the scientists investigated how it prolongs the lives of flies, they discovered a new drug target that could slow aging – a molecule called glycogen synthase kinase-3 (GSK-3).
“To improve our quality and length of life we must delay the onset of age-related diseases by extending the healthiest period of our lives...
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