gold nanorods tagged posts

Scientists discover a method to turn stubby gold nanorods into gold nanowires of impressive length. The metal wires could be valuable for sensing, diagnostic, imaging and therapeutic applications. A boost of vitamin C helped Rice University scientists turn small gold nanorods into fine gold nanowires.

Common, mild ascorbic acid is the not-so-secret sauce that helped the Rice lab of chemist Eugene Zubarev grow pure batches of nanowires from stumpy nanorods without the drawbacks of previous techniques.

“There’s n...

Georgia Tech’s Regents Professor Mostafa El-Sayed (front) is one of the most highly decorated and cited living chemists. With his team for this research from left to right: Yue Wu, Professor Ronghu Wu, and Yan Tang. Credit: Georgia Tech / Christopher Moore

Researchers have found a way to virtually halt cell migration, a key component in metastasis, in vitro, in human cells. In past in vivo studies in mice, treated cancer did not appear to recur. No significant side effects were observed. Cancer cells often cover themselves bristly leg-like protrusions that enable them to creep. The researchers have used minuscule gold rods heated gently by a laser to mangle the protrusions, according to a new study.

The treatment can also easily kill cancer cells, but in this experiment, it was vital to sp...

Gold nanorods within the blood vessels of a mouse ear appear green. The lower right shows vessels within a tumor that lies under the skin. Credit: de la Zerda lab

The technique, called MOZART (for MOlecular imaging and characteriZation of tissue noninvasively At cellular ResoluTion), could one day allow scientists to detect tumors in the skin, colon or esophagus, or even to see the abnormal blood vessels that appear in the earliest stages of macular degeneration – a leading cause of blindness. The technique could allow doctors to monitor how an otherwise invisible tumor under the skin is responding to treatment, or to understand how individual cells break free from a tumor and travel to distant sites.

A technique exists for peeking into a live tissue several millimeters under the skin, rev...

Kyoto University’s Institute team coated gold nanorods with lipoprotein. This allowed the nanorods to bind efficiently to nerve cell membranes bearing a pain receptor called TRPV1 (transient receptor potential vanilloid type 1). Near-infrared light was then applied to the nanorod-coated pain receptors. The nanorods heated up, activating the pain receptors to allow an influx of calcium ions through the membrane. Prolonged activation of TRPV1 is known to subsequently lead to their desensitization, bringing pain relief. Importantly, heating the gold nanorods enabled safe activation of the TRPV1 pain receptors alone, without affecting the membrane in which they lie.

Previous studies had shown that magnetic nanoparticles are also able to activate TRPV1 receptors by applying a magnetic fie...