A putative model attempting to depict different levels of genomic organization that may be associated with specific acquired spermatozoal defects. The sperm nucleus is broken down sequentially until the raw DNA. In human spermatozoa it is proposed that up to 15% of histone complexed DNA may remain after spermiogenesis while the remainder is all protamine complexed. For further information see Ward and Coffey (1991).
A dad’s food intake, drugs, exposure to toxic products and even stress can affect the development and health not only of his unborn children, but even of his grandchildren. They have discovered histones may play a crucial role in the process.
In the past, most epigenetics has focused on a process involving DNA and methyl groups that turn up or down the expression of specific ge...
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