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Type 2 Diabetes Accelerates Brain Aging and Cognitive Decline

Aging effects on the brain, further exacerbated in type 2 diabetes. Image credit: Lilianne Mujica-Parodi (CC BY 4.0)

Scientists have demonstrated that normal brain aging is accelerated by approximately 26% in people with progressive type 2 diabetes compared with individuals without the disease, reports a study published today in eLife.

The authors evaluated the relationship between typical brain aging and that seen in type 2 diabetes, and observed that type 2 diabetes follows a similar pattern of neurodegeneration as aging, but which progresses faster. One important implication of this finding is that even typical brain aging may reflect changes in the brain’s regulation of glucose by insulin.

The results further suggest that by the time type 2 diabetes is formally diagnosed, the...

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