Guardian of the Genome tagged posts

The ‘Guardian of the Genome’ Protects against Cardiovascular Disease

The 'guardian of the genome' protects against cardiovascular disease
The analysis of human samples and animal experiments demonstrate that the presence of p53 gene mutations in the blood increases the risk of developing atherosclerosis, the principle cause of cardiovascular disease. Credit: CNIC

A team at the Centro Nacional de Investigaciones Cardiovasculares (CNIC), working in collaboration with institutes in the U.S., has demonstrated that acquired mutations in the gene encoding the protein p53 contribute to the development of atherosclerotic cardiovascular disease.

Known as the “guardian of the genome,” p53 helps to maintain the integrity of the hereditary material inside cells by regulating multiple cell functions in response to cellular stresses.

Every day, an adult person generates hundreds of thousands of blood cells...

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