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Gut neurons help body fight inflammation with immune-regulating molecule

cells stained red and green
Neurons (red) in the enteric nervous system contain ADM2 (green) along their nerve fibers. Image credit: Victoria Ribeiro de Godoy, Drs. Jazib Uddin and David Artis.

Neurons in the gut produce a molecule that plays a pivotal role in shaping the gut’s immune response during and after inflammation, according to a new study by Weill Cornell Medicine investigators. The findings suggest that targeting these neurons and the molecules they produce could open the door to new treatments for inflammatory bowel disease and other disorders driven by gut inflammation.

Hundreds of millions of neurons make up the enteric nervous system, the “second brain” of the body, where they orchestrate essential functions of the gut such as moving food through the intestines, nutrient absorption and blood flo...

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