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    Hair follicle stem cells (HFSCs) tagged posts

    The Bald Truth: Altered Cell Divisions cause Hair Thinning

    March 18, 2021, Categories  Biology/Biotechnology, Health/Medical

    Schematic model of the distinct types of stem cell divisions determine HF homeostasis and aging.
    Young HFSCs undergo symmetric cell divisions (SCDs) and asymmetric cell divisions (ACDs) to generate new bulge cells for their self-renewal and expansion. Whereas aged HFSCs provoke hemidesmosomal instability including COL17A1 and undergo stress response (SR) type ACDs to induce epidermal differentiation that triggers their delamination, thereby causing stepwise miniaturization of HFs and hair thinning and loss.

    Researchers have identified a novel mechanism underlying hair thinning and loss during aging...

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    Hair thinning by stem cell loss

    February 5, 2016, Categories  Biology/Biotechnology, Health/Medical

    Why people lose their locks in old age may be related to the aging of hair follicle stem cells, two new studies suggest. Though it is known that mammals that live for longer lifespans lose their hair, the mechanisms underlying this fate have been a mystery. Hair follicle stem cells (HFSCs), which generate the sacs or follicles that produce hair, keep hair growth going repeatedly over time.

    Surprisingly, they have even been shown, in mice experiments, to resist aging. To better understand the role HFSCs might play in aging-associated hair loss, Hiroyuki Matsumura and colleagues studied hair follicles in a mouse model of accelerated hair loss...

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