hair loss tagged posts

Throwing a ‘spanner in the works’ of our cells’ machinery could help fight cancer, fatty liver disease… and hair loss

mitochondria
Credit: Pixabay/CC0 Public Domain

Fifty years since its discovery, scientists have finally worked out how a molecular machine found in mitochondria allows us to make the fuel we need from sugars, a process vital to all life on Earth.

Scientists at the Medical Research Council (MRC) Mitochondrial Biology Unit, University of Cambridge, have worked out the structure of this machine and shown how it operates like the lock on a canal to transport pyruvate—a molecule generated in the body from the breakdown of sugars—into our mitochondria.

Known as the mitochondrial pyruvate carrier, this molecular machine was first proposed to exist in 1971, but it has taken until now for scientists to visualize its structure at the atomic scale using cryo-electron microscopy, a technique used to ...

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The Bald Truth: Altered Cell Divisions cause Hair Thinning

Schematic model of the distinct types of stem cell divisions determine HF homeostasis and aging.
Young HFSCs undergo symmetric cell divisions (SCDs) and asymmetric cell divisions (ACDs) to generate new bulge cells for their self-renewal and expansion. Whereas aged HFSCs provoke hemidesmosomal instability including COL17A1 and undergo stress response (SR) type ACDs to induce epidermal differentiation that triggers their delamination, thereby causing stepwise miniaturization of HFs and hair thinning and loss.

Researchers have identified a novel mechanism underlying hair thinning and loss during aging...

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Hair thinning by stem cell loss

Why people lose their locks in old age may be related to the aging of hair follicle stem cells, two new studies suggest. Though it is known that mammals that live for longer lifespans lose their hair, the mechanisms underlying this fate have been a mystery. Hair follicle stem cells (HFSCs), which generate the sacs or follicles that produce hair, keep hair growth going repeatedly over time.

Surprisingly, they have even been shown, in mice experiments, to resist aging. To better understand the role HFSCs might play in aging-associated hair loss, Hiroyuki Matsumura and colleagues studied hair follicles in a mouse model of accelerated hair loss...

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