Left, the P domain on human norovirus attaches to human cells via binding to HBGA. Human IgA antibody 5I2 interferes with this attachment by physically blocking the HBGA recognition site on the P domain. Courtesy of S. Shanker, B.V.V. Prasad and M. Estes
A mechanism by which human antibodies target and block noroviruses has been found. It opens the possibility of developing therapeutic agents against this virus that causes the death of about 200,000 children every year. “Some people infected with norovirus do not get sick,” said Dr. B V Venkataram Prasad, professor of virology and the Alvin Romansky Chair in biochemistry at Baylor. “We wanted to understand how
these protective human antibodies work.”
The researchers screened and isolated protective antibodies from human blood and discovere...
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