hearing loss tagged posts

Researchers at UCL and UCLH have successfully completed the first trial of a therapy designed to restore hearing loss. The REGAIN trial, the results of which were published in Nature Communications, was the first study of a treatment aimed at restoring lost hearing, focusing on a drug with the technical name gamma-secretase inhibitor LY3056480.

The researchers found that while the t...

Medical researchers have developed a novel way for a drug to zero in on damaged nerves and cells inside the ear. Credit: © Pixsooz / Fotolia

Researchers at USC and Harvard have developed a new approach to repair cells deep inside the ear – a potential remedy that could restore hearing for millions of elderly people and others who suffer hearing loss. The lab study demonstrates a novel way for a drug to zero in on damaged nerves and cells inside the ear. It’s a potential remedy for a problem that afflicts two-thirds of people over 70 years and 17% of all adults in the United States.

“What’s new here is we figured out how to deliver a drug into the inner ear so it actually stays put and does what it’s supposed to do, and that’s novel,” said Charles E...

1. photograph of large clonal colonies of cochlear progenitor cells formed from single cells and converted into high purity colonies hair cells (magenta) with intricate hair bundles (cyan). Credit: Will McLean, Ph.D.  2. Newly formed cochlear hair cells contain intricate hair bundles with many stereocilia (critical for sensing sound) and other components that are critical for proper function and neural transmission. (Credit: Will McLean)

Researchers discover a drug combination that can regenerate hair cells. Within the inner ear, thousands of hair cells detect sound waves and translate them into nerve signals that allow us to hear speech, music, and other everyday sounds. Damage to these cells is one of the leading causes of hearing loss, which affects 48 million Americans...