Stromal Hh activation attenuates colonic tumour development.
Many types of cancer are caused by gene mutations in the signalling pathways that control cell growth, such as the hedgehog signalling pathway. A new study from the Karolinska Institutet now surprisingly shows that in colon cancer hedgehog signalling has a protective function. Mutations that lead to the activation of hedgehog signalling are the cause of almost all cases of basal cell carcinoma, BCC (a common form of skin cancer) and certain types of brain tumours.
Previous studies have indicated that hedgehog signalling is also important in other types of cancer, such as colon cancer – one of the commonest types of cancer in Sweden...
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